This research examines the dynamic relationship between regionalism and LGBTQ encounters with, and resistance to, political homo- and transphobia in the Middle East and North Africa (MENA). Existing literature on LGBTQ politics has devoted sparse attention to how movements navigate contexts where political opportunities for mobilization are closed, especially as it pertains to such movements in the MENA region. While this region is correctly attributed with being repressive in the domain of gender and sexuality politics, we have overlooked that LGBTQ movements are mobilizing there in innovative ways. The project uses novel methods to investigate both the impact of political homo/transphobia on LGBTQ communities and shining a light on the strategies employed by transnational LGBTQ social movements in response to it. A key argument is that LGBTQ resistance manifests through transnational solidarity, wherein LGBTQ social movements have emerged over the past 20 years across MENA countries. These movements extend beyond their local contexts, connecting through region-wide and transnational networks. In doing so, they develop new tactical repertoires of activism and new languages of queer resistance. I thus emphasize how groups navigate repression on behalf of their own human security, thereby engaging a scholarship on movements and socio-political change in an original way. Rooted in political science and sociology, it holds potential for charting the landscape of LGBTQ repression and rights in the MENA region, making theoretical and methodological contributions to shine light on transnational queer resistances and what they mean for the disciplines.